Phenol → HCID 14789659, compound

Participants

Reaction Steps

Stir a solution of TRANS-2,3-dihydro-2-dimethylamino methyl-inden-1-ol (7.65 g, 0.04 M) triphenylphosphine (11.54 g, 0.044 M), and phenol (4.14 g, 0.044 M) in 100 ml of tetrahydrofuran. Slowly add a solution of diethyl azodicarboxylate in 50 ml of tetrahydrofuran dropwise. Stir the mixture overnight and evaporate the solvent. Take up the residue in ether, filter insoluble material and reconcentrate. Chromatograph the residue on silica gel eluting with ether to yield two isomers, CIS and TRANS, with the CIS isomer eluting first.

Provenance & Evidence