反应详情

A solution of 269.0 g (1.12 mol) of sodium sulfide hydrate and 12.0 g of tetrabutylammonium hydrogen sulfate (phase transfer catalyst) in 300 ml of water is introduced into a reaction vessel provided with a stirrer and thermometer. 212.6 g (1.52 mol) of 4-methylbenzyl chloride are added dropwise at below 40° C. in the course of 30 minutes (min), while stirring intensively. The reaction mixture is stirred at room temperature (RT) for 4 1/2 hours (h) and then at 50°-60° C. for 1/2 h. The reaction mixture is cooled to 0°-5° C. and kept at this temperature for 1/2 h. The reaction mixture is filtered and the residue is dissolved in about 2 liters of ethyl acetate. The organic phase is extracted twice by shaking with deionized water (pH ~6) and dried over MgSO4. The ethyl acetate is removed on a rotary evaporator. The residue is dried overnight at RT under a high vacuum. 174.8 g (95% of theory) of di-(p-methylbenzyl) sulfide are obtained as slightly yellowish white crystals having a melting point of 74°-76° C.

1. customprovided with a stirrer
2. stirringThe reaction mixture is stirred at room temperature (RT) for 4 1/2 hours (h)
3. temperatureThe reaction mixture is cooled to 0°-5° C.
4. waitkept at this temperature for 1/2 h
5. filtrationThe reaction mixture is filtered
6. dissolutionthe residue is dissolved in about 2 liters of ethyl acetate
7. extractionThe organic phase is extracted twice
8. stirringby shaking with deionized water (pH ~6)
9. dry with materialdried over MgSO4
10. customThe ethyl acetate is removed on a rotary evaporator
11. customThe residue is dried overnight at RT under a high vacuum