反应详情

温度

90 °C

Fifty grams of 1,3-diaminopentane (99%, 0.485 mole), 116 g (1.07 moles) adiponitrile and 2.3 g Raney® nickel were charged to a 300 cc autoclave reactor. The mixture was stirred and heated at 90° C. and 650 psig hydrogen pressure for 10 hours. The mixture was cooled and filtered under nitrogen. Capillary GC analysis of the filtered product indicated a 56% conversion of 1,3-diaminopentane and 59% yield of 2-(4-cyanobutyl)-4-ethylhexahydropyrimidine.

1. temperatureThe mixture was cooled
2. filtrationfiltered under nitrogen