HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Amino-3-chloro-5-pyridyl bromomethyl ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(6-Amino-5-chloropyridin-3-YL)ethan-1-one | HCID 14371383 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Amino-3-chloro-5-pyridyl bromomethyl ketone | HCID 14371384 | 74.2% |
Reaction Steps
16 g (0.1 mol) of bromine are added dropwise to a solution of 17.05 g (0.1 mol) of 2-amino-3-chloro-5-acetylpyridine in a mixture of 19.3 g of hydrogen bromide (47% strength aqueous solution; 0.11 mol) and 500 ml of glacial acetic acid. The mixture is subsequently stirred for a further two hours, brought to pH 8 and extracted with ethyl acetate. Drying and evaporation give 18.5 g (74%) of the title compound of melting point 134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05149822 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-f2e298784d3f433cb575535c54936029 |
| Source note | uspto-grants-1992_09 |