3,4-Diaminopyridine → HCID 178432317, compound

HRID 1886177Notes

Reaction equation

HRID 1886177 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:9](OC(=O)C)(=O)[CH3:10]>>[CH3:9][C:10]1[NH:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 59183,4-DiaminopyridineHCID 7918Acetic Anhydride

Product 1

HCID 178432317HCID 178432317, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 3,4-diaminopyridine (20.0 g, 183 mmol) and acetic anhydride (360 ml) was heated at 100° C. for 16 hours. The excess reagent was removed under reduced pressure, and the residue was purified by flash chromatography eluting with ethyl acetate:methanol, 3:1. The product was a brown solid, (15.5 g, 64%).

Workup

  1. customThe excess reagent was removed under reduced pressure
  2. customthe residue was purified by flash chromatography
  3. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-296d4e585873426f861fae4c27447157
Source dataset
uspto-grants-1992_09
Patent number
US05149814

Reaction notes

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