HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyphenylacetic acid → Benzyl 2-(4-hydroxyphenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyphenylacetic acid | HCID 127 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzyl 2-(4-hydroxyphenyl)acetate | HCID 11107524 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
4-Hydroxyphenylacetic acid (2.0 kg) is dissolved in DMF (8 L) and lithium carbonate (1.07 kg) is added in one portion followed by benzyl bromide (1.88 L). The mixture is heated to 100° C. over 1 hour, aged for 3 hours. The mixture is cooled to 85° C. and transferred into a 50 L vessel and quenched with 2N HCl (10 L).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05149838 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-7c62da3dad8646539173a97f038bf291 |
| Source note | uspto-grants-1992_09 |