HCID 67636931, compound → HCID 21121479, compound

HRID 1886251Notes

Reaction equation

HRID 1886251 reaction equation
[CH2:1]([N:5]([CH3:42])[C:6](=[O:41])[CH2:7][S:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C@H:21]2[CH2:38][C@@:36]3([CH3:37])[C@@H:32]([CH2:33][CH2:34][C:35]3=[O:39])[C@H:31]3[C@H:22]2[C:23]2[CH:24]=[CH:25][C:26]([OH:40])=[CH:27][C:28]=2[CH2:29][CH2:30]3)=[CH:17][CH:16]=1)[CH2:2][CH2:3][CH3:4]>CO>[CH2:1]([N:5]([CH3:42])[C:6](=[O:41])[CH2:7][S:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C@H:21]2[CH2:38][C@@:36]3([CH3:37])[C@@H:32]([CH2:33][CH2:34][C@@H:35]3[OH:39])[C@H:31]3[C@H:22]2[C:23]2[CH:24]=[CH:25][C:26]([OH:40])=[CH:27][C:28]=2[CH2:29][CH2:30]3)=[CH:17][CH:16]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 67636931HCID 67636931, compound

Product 1

HCID 21121479HCID 21121479, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

One reduces the N-butyl-(5-(4-(3-hydroxy-17-oxo-estra-1,3,5(10)-trien-11beta-yl)-phenoxy)-pentylthio)-N-methyl acetamide obtained in Example 76 using sodium borohydride in methanol. In this way one obtains the expected product. [alpha]D =-32.5° (c=0.1% CHCl3)

Sources & evidence

ORD record
ord-cc689e5d67ab4ec4a9094ab3dc716737
Source dataset
uspto-grants-1992_09
Patent number
US05149696

Reaction notes

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