Dichloromethane → HCID 19877590, compound

Participants

Reaction Steps

A dry methylene chloride solution of 102.8 mg (0.34 mmol) of 4-(6-methoxy-2-naphthylthio)-3-oxobutanoate was cooled to -78° C., one hundred (100) μl (0.97 mmol) of boron tribromide was added, and the reaction was carried out from -78° C. to room temperature for 2 hours. Then dry methanol (3 ml) was added, and the mixture was stirred over one day and night at room temperature. The mixture was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, followed by drying over anhydrous magnesium sulfate. The solvent was evaporated under a reduced pressure, and the desired sulfideketone derivative was obtained by silica gel column chromatography. Yield: 81.8 mg (83%).

Provenance & Evidence