2-[(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic Acid → 4-methyl-3-oxo-N-phenylpentanamide

HRID 1886296Notes

Reaction equation

HRID 1886296 reaction equation
NCC[C@H:4]1OC(C)(C)[O:7][C@@H:6]([CH2:12][C:13]([OH:15])=O)[CH2:5]1.[NH2:16][CH2:17][CH2:18][C@H:19]1OC2(CCCC2)O[C@@H:21]([CH2:29]C(O)=O)[CH2:20]1.N[CH2:34]C[C@H]1OC2(CCCCC2)O[C@@H](CC(O)=O)C1>>[CH3:34][CH:5]([CH3:4])[C:6](=[O:7])[CH2:12][C:13]([NH:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:29]=1)=[O:15]

Participants

4

Reactant 3

HCID 117906292-[(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic AcidHCID 15045133(+/-)-cis-9-(2Aminoethyl)-6,10-dioxaspiro[4.5]decane-7-acetic acidHCID 15045142(2R-cis)-4-(2-aminoethyl)-1,5-dioxaspiro[5.5]undecane-2-acetic acid

Product 1

HCID 102198994-methyl-3-oxo-N-phenylpentanamide

Procedure

A compound according to claim 6 selected from the group consisting of (4R-cis)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid; [2R-(2α,4α,6α)]-6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetic acid; [2S-(2α,4β,6β)]-6-(2-aminoethyl)-2-phenyl-1,3-dioxane-4-acetic acid; (7R-cis)-9-(2-aminoethyl)-6,10-dioxaspiro [4.5]decane-7-acetic acid; (2R-cis)-4-(2-aminoethyl)-1,5-dioxaspiro[5.5]undecane-2-acetic acid; (4R-cis)-4-(2-aminoethyl)-1,3-dioxane-4-acetic acid; [2R-(2α,4α,6α)]-6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetic acid; and [2S-(2α,4β,6β)]-6-(2-aminoethyl)-2-methyl-1,3-dioxane-4-acetic acid.

Sources & evidence

ORD record
ord-30525a63c5e54a4a91ab9529063933a0
Source dataset
uspto-grants-1992_09
Patent number
US05149837

Reaction notes

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