1-Hexanol → (R)-(+)-2,3-EPOXYPROPYL HEXYL ETHER

Participants

Reaction Steps

6 ml of n-hexanol was added dropwise to a mixture of 40 g of 50% sodium hydroxide solution, 24 g of (R)-epichlorohydrine as used in the Synthetic Example 1 and 400 mg of tetrabutylammoniumhydrogen sulfate, under cooling at 20° to 25° C. The reaction solution was stirred at the same temperature for 3 hours and added with water, and then the product was extracted into ether. The extracted product was distilled under reduced pressure to obtain 3.35 g of (R)-n-hexylglycidylether.

Provenance & Evidence