HCID 54323423, compound → HCID 19875685, compound

Participants

Reaction Steps

80 ml of 12N hydrochloric acid was added to 2.0 g of 4-[3-{3-(3-phosphonopropyl)ureido}phenyl]-3-methyl-5-mercaptotriazole (9) thus obtained. The system was allowed to undergo reaction at a temperature of 90° C. over 8 hours. After the completion of the reaction, hydrochloric acid was distilled off under reduced pressure. 20 ml of water was added to the system. The system was then dissolved under heating. Sodium chloride was gradually added to the solution to deposit crystals. The addition of sodium chloride continued until the solution was somewhat whitened. The solution thus whitened was then heated so that it was homogenized. The solution was naturally filtered, and then allowed to stand. As a result, a crystalline 4-[3-{3-(3-phosphonopropyl)ureido}phenyl]-3-methyl-5-mercaptotriazole (10) was deposited. (Yield: 0.58 g (33%); m.p. 195° C.)

Provenance & Evidence