Enalapril Maleate → Enalapril

HRID 1886334Notes

Reaction equation

[CH3:1][CH2:2][O:3][C:4]([C@@H:6]([NH:15][C@H:16]([C:18]([N:20]1[C@H:24]([C:25]([OH:27])=[O:26])[CH2:23][CH2:22][CH2:21]1)=[O:19])[CH3:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5].C(/C(O)=O)=C/C(O)=O.C(/C(=C\C([O-])=O)/C([O-])=O)CCCCCCCCCCCCCCCCC.[Na+].[Na+]>>[CH3:1][CH2:2][O:3][C:4]([C@@H:6]([NH:15][C@H:16]([C:18]([N:20]1[C@H:24]([C:25]([OH:27])=[O:26])[CH2:23][CH2:22][CH2:21]1)=[O:19])[CH3:17])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:5]

Participants

Reactant 2

HCID 5388961Enalapril Maleate

HCID 86583066HCID 86583066, compound

Product 1

HCID 5388962Enalapril

Procedure

29.4 g of 85% pure enalapril hydrogen maleate (contains 15% HPMC as film coating as in Example 9), 480 g of microcrystalline cellulose and 480.6 g of modified free-flowing starch are mixed. In a second step, 10 g of sodium stearylfumarate are mixed into this mixture. 1 kg of this mixture is compressed directly, without other granulation steps, to tablets having a final weight of 100 mg.

Sources & evidence

ORD record: ord-4805857d20da470cb564a6074e4209ef
Source dataset: uspto-grants-1992_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05151433

Reaction notes

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