反应详情

A solution of 10 parts of 4-[1-(1H-imidazol-1-yl)-2-methylpropyl]-2-nitrobenzenamine, 20 parts of ethyl β-oxobenzenepropanoate and 174 parts of benzene was stirred for 36 hours at reflux temperature. After cooling, the reaction mixture was evaporated. The residue was purified by column chromatography over silica gel using a mixture of dichloromethane and methanol (98:2 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 7 parts (44.8%) of N-[4-[1-(1H-imidazol-1-yl)-2-methylpropyl]-2-nitrophenyl]-β-oxobenzenepropanamide; mp. 106° C. (interm. 96).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated
4. customThe residue was purified by column chromatography over silica gel using
5. additiona mixture of dichloromethane and methanol (98:2 by volume) as eluent
6. customThe pure fractions were collected
7. customthe eluent was evaporated