Sodium Hydroxide → HCID 19875847, compound

HRID 1886364Notes

Reaction equation

HRID 1886364 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:21])[CH2:17]C(=O)C)=[C:11]([N+:22]([O-])=O)[CH:10]=2)[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[C:9]2[CH:10]=[C:11]3[C:12](=[CH:13][CH:14]=2)[NH:15][C:16](=[O:21])[CH:17]=[N:22]3)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19875872HCID 19875872, compound

Product 1

HCID 19875847HCID 19875847, compoundYield 100%

Conditions

Temperature
80 °C

Procedure

A mixture of 12 parts of N-[4-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-2-nitrophenyl]-3-oxobutanamide and 120 parts of a sodium hydroxide solution 6.5% was stirred for 15 minutes at 80° C. After cooling, the product was obtained, yielding 10.25 parts (100%) of 6-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-2(1H)-quinoxalinone, N4 -oxide (comp. 175).

Workup

  1. temperatureAfter cooling
  2. customthe product was obtained

Sources & evidence

ORD record
ord-9d758273ad324187a6119b627811f0da
Source dataset
uspto-grants-1992_09
Patent number
US05151421

Reaction notes

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