Benzyloxyamine hydrochloride → HCID 53866658, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (±)-2-(3-pyridyl)cyclopentanone (2.0 g) and benzyloxyamine hydrochloride (1.98 g) in anhydrous pyridine was stirred at 60° C. for 4.5 hours. The pyridine was removed in vacuo (40° C., 0.2 mmHg), the residue was dissolved in chloroform (75 ml), washed with water (4×75 ml), dried over magnesium sulphate and evaporated. The residual oil was purified by flash chromatography on silica, eluting with chloroform/methanol (100/1) to give (±)-2-benzyloxyimino -1-(3-pyridyl)cyclopentane (mixture of syn and anti isomers, 1:3), a pale yellow oil (2.91 g).

Provenance & Evidence