2-Trifluoromethylbenzenesulphonyl chloride → HCID 14650537, compound

HRID 1886440Notes

Reaction equation

HRID 1886440 reaction equation
[NH2:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=2)[O:5][C:4]([CH3:15])([CH3:14])[CH:3]1[OH:16].[F:17][C:18]([F:30])([F:29])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26]>N1C=CC=CC=1>[C:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[O:5][C:4]([CH3:14])([CH3:15])[C@@H:3]([OH:16])[C@@H:2]2[NH:1][S:25]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:18]([F:17])([F:29])[F:30])(=[O:27])=[O:26])#[N:13]

Participants

4

Reactant 2

HCID 1366162-Trifluoromethylbenzenesulphonyl chlorideHCID 33905134-Amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Product 1

HCID 14650537HCID 14650537, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1 g of 4-amino-6-cyano-2,2-dimethyl-3-hydroxychroman and 1 g of 2-trifluoromethylbenzenesulfonyl chloride in 25 ml of pyridine is stirred at room temperature for 18 hours.

Sources & evidence

ORD record
ord-f9740f1ea6d74cbabdd66d1df8dee095
Source dataset
uspto-grants-1992_09
Patent number
US05151442

Reaction notes

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