p-Chlorothiophenol → HCID 14650541, compound

HRID 1886441Notes

Reaction equation

HRID 1886441 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8]([CH3:14])([CH3:13])[CH:7]1[O:15][CH:6]21)#[N:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([SH:23])=[CH:19][CH:18]=1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>O1CCOCC1>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][C@@H:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([C:1]#[N:2])[CH:4]=3)[O:9][C:8]([CH3:14])([CH3:13])[C@H:7]2[OH:15])=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 7815p-ChlorothiophenolHCID 66854Benzyltrimethylammonium hydroxideHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochroman

Product 1

HCID 14650541HCID 14650541, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2 g of 6-cyano-2,2-dimethyl-3,4-epoxychroman and 1.8 g of parachlorothiophenol in 15 ml of dioxane and 0.3 ml of a 35% methanolic solution of benzyltrimethylammonium hydroxide is refluxed for 5 hours.

Workup

  1. temperatureis refluxed for 5 hours

Sources & evidence

ORD record
ord-52b8a5e505f94a82b726559c477c1af6
Source dataset
uspto-grants-1992_09
Patent number
US05151442

Reaction notes

Loading…