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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1886445Generated: October 31, 2026

Phosphorus oxide (P4O10) → 6-chloro-2,3-dihydro-8-nitro-4(1H)-quinolinone

https://huagongshe.com/reaction/1886445

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxide (P4O10)HCID 14812—
Reactant3-(4-Chloro-2-nitroanilino)propanoic acidHCID 304733—
SolventTolueneHCID 1140—
Product6-chloro-2,3-dihydro-8-nitro-4(1H)-quinolinoneHCID 1987600567.5%

Reaction Steps

Starting from 3-(4-chloro-2-nitrophenylamino)propionic acid (40.0 g), phosphorus pentoxide (70.0 g) and toluene (300 ml), 6-chloro-2,3-dihydro-8-nitro-4(1H)-quinolinone (yield 25.0 g) was obtained in a manner similar to Step 1 of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05151431
Source datasetuspto-grants-1992_09
ORD IDord-b83fd9e9c8114d11a7baad81ace78f6c
Source noteuspto-grants-1992_09