HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 19876062, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(5-indolyl)methyl-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine | HCID 10040727 | — |
| Product | HCID 19876062 | HCID 19876062 | 77% |
Reaction Steps
To a solution of the product of Example 2, Step A (200 mg, 0.66 mmol) in 7 mL of DMF was added NaH (53 mg, 1.23 mmol) and the mixture stirred for a few minutes. Isatoic anhydride (160 mg, 0.99 mmol) was added to the reaction mixture and it was stirred for 16 hours. The solvent was removed in vacuo and the resultant residue was flash column chromatographed with 15% of (10/1) mixture of MeOH/NH4OH in CHCl3 to give titled compound (236 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05151435 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-36d30a7746574e089c433f1efd038d11 |
| Source note | uspto-grants-1992_09 |