Sodium Hydroxide → HCID 10048776, compound

Participants

Reaction Steps

To a solution of 75 mg (0.17 mmol) of the product of Example 14, Step B in 3 mL of methanol was added 2.0 mL of 1N NaOH. The mixture was stirred for 16 hours. The volatiles were removed in vacuo and the water removed azeotropically with toluene. The clear oil was flash chromatographed with 80:20:2 CHCl3 /methanol/NH4OH to yield the titled compound (58 mg, 80%).

Provenance & Evidence