Acetic Anhydride → N-Acetyl-2-aminotetralin

HRID 1886485Notes

Reaction equation

[NH2:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([NH:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:14])[CH3:13]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 346772-Aminotetralin

Product 1

HCID 10058319N-Acetyl-2-aminotetralinYield 65%

Procedure

Using a procedure similar to that described in Example 1, 1.50 g of 2-amino-tetralin yielded 1.01 g (65%) of 2-acetamido-tetralin following treatment with acetic anhydride.

Sources & evidence

ORD record: ord-f3732dd1c4c34f63bf1d3b1525d4860c
Source dataset: uspto-grants-1992_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05151446

Reaction notes

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