Hydrochloric Acid → HCID 22846170, compound

Participants

Reaction Steps

Methyl trans-2-methyl-4-oxocyclopentanecarboxylate [K. Kojima et at., Chem. Pharm. Bull., 33, 2750 (1985)] (495 mg) was dissolved in methanol (3 ml), and a 1N aqueous solution of sodium hydroxide (3.5 ml) was added to the solution at 0° C. After the mixture was stirred at room temperature for 1 hour, it was acidified with dilute hydrochloric acid, followed by extraction with ether. The extract was concentrated to dryness and the residue was subjected to silica gel column chromatography with ethyl acetate-chloroform (1:1) as eluent, and the eluted fractions were combined and concentrated to dryness to afford the title compound (219 mg) as crystals.

Provenance & Evidence