Ammonia → 2-Cyclopentyl-6-methylcyclohexylamine

Participants

Reaction Steps

In a 5 l stirred autoclave, a mixture of 485 g of 2-cyclopentyl-6-methylphenol and 551 g of ammonia is subjected to reductive amination in the presence of a powder catalyst containing 10% by weight of palladium and 5% by weight of praseodymium oxide on alumina at 230° C. and under a hydrogen pressure of 300 bar until the pressure remains constant. After the catalyst has been separated off, 484 g (95% yield) of crude 2-cyclopentyl-6-methylcyclohexylamine are obtained, and can be used without further purification in the next stage.

Provenance & Evidence