Potassium Hydroxide → HCID 14534587, compound

HRID 1886559Notes

Reaction equation

HRID 1886559 reaction equation
[OH-].[K+].C([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:9]=1[Cl:18])(=O)C>C(O)C>[C:14]([C:10]1[C:9]([Cl:18])=[C:8]([CH:13]=[CH:12][CH:11]=1)[CH2:7][OH:6])([CH3:17])([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14534586HCID 14534586, compound

Product 1

HCID 14534587HCID 14534587, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

21.0 g (0.39 mole) of potassium hydroxide are added to a solution of 62.6 g (0.26 mole) of 3-tert-butyl-2-chlorobenzyl acetate in 400 ml of ethanol. The reaction mixture is stirred for 6 hours at 50° C. and evaporated and the residue is taken up with water. The aqueous mixture is extracted with dichloromethane. 51 g (quantitative) of 3-tert-butyl-2-chlorobenzyl alcohol of boiling point 103°-105° C./0.2 mbar are obtained from the organic phase.

Workup

  1. customevaporated
  2. extractionThe aqueous mixture is extracted with dichloromethane

Sources & evidence

ORD record
ord-a1fa589c7efc46c9aeb123244d6e31af
Source dataset
uspto-grants-1992_09
Patent number
US05151548

Reaction notes

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