Diisopropyl Ether → HCID 141558699, compound

Participants

Reaction Steps

p-Methoxybenzyl 7β-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-[(triphenylphosphoranylidene)methyl]-3-cephem-4-carboxylate (4 g) and 5-pyrimidinaldehyde (0.8 g) were stirred for 12 hours in dichloromethane (40 ml). The reaction mixture was concentrated to about 15 ml and then subjected to chromatography on a silica gel column. Relevant fractions were combined and concentrated, whereby an oily matter was obtained. It was added dropwise to a mixed solvent of isopropyl ether (20 ml) and n-hexane (80 ml). The resulting precipitate was collected by filtration, whereby the title compound (1.5 g) was obtained.

Provenance & Evidence