HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → N-(20-Bromoeicosyl)phthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | 20-Bromoicosan-1-ol | HCID 5176653 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(20-Bromoeicosyl)phthalimide | HCID 19698940 | 66% |
Reaction Steps
Following general procedure A, 69.4 mmol (26.2 g) of 20-Bromoeicosan-1-ol, 76.3 mmol (20.0 g) of triphenylphosphine, 76.3 mmol (11.2 g) of phthalimide and 76.3 mmol (15.5 mL) of diisopropyl azo dicarboxylate were reacted in 300 mL of tetrahydrofuran for 1 d and the mixture was processed accordingly. The crude product was purified by column chromatography (toluene). Yield 66%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501199B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-9dcc29fbdba84880a314def9c8443d3f |
| Source note | uspto-grants-2013_08 |