HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(4-chloro-3-nitrophenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Chloro-3-nitroaniline | HCID 12477 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-chloro-3-nitrophenyl)methanesulfonamide | HCID 3755760 | 92.2% |
Reaction Steps
A mixture of 4-chloro-3-nitroaniline (5.0 g, 29 mmol), methanesulfonyl chloride (2.37 mL, 30.4 mmol) and pyridine (5.9 mL, 72.4 mmol) in THF (100 mL) was stirred for 24 h. Poured in 1M HCl (500 mL). The resulting precipitate was filtered and air-dried to provide the title compound as a solid (6.7 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501238B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-0c2818d2868d4970981cc7ca88de3e1e |
| Source note | uspto-grants-2013_08 |