Trimethylsilyl iodide → HCID 66780718, compound

HRID 1886877Notes

Reaction equation

HRID 1886877 reaction equation
[Na:1].[N:2]1([C:11]([CH2:13][C@H:14]([CH2:21][OH:22])[O:15][CH2:16][P:17]([OH:20])([OH:19])=[O:18])=[O:12])[CH:10]=[C:8](C)[C:6](=[O:7])[NH:5][C:3]1=[O:4].N1(C(C[C@H](CO)OCP(OC(C)C)(OC(C)C)=O)=O)C=CC(=O)NC1=O.I[Si](C)(C)C>>[Na:1].[N:2]1([C:11]([CH2:13][C@H:14]([CH2:21][OH:22])[O:15][CH2:16][P:17]([OH:19])([OH:20])=[O:18])=[O:12])[CH:10]=[CH:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]

Participants

4

Reactant 3

HCID 85247Trimethylsilyl iodideHCID 11326794HCID 11326794, compoundHCID 66781128HCID 66781128, compound

Product 1

HCID 66780718HCID 66780718, compoundYield 34%

Procedure

This compound was prepared as described for 3f, using 21 (154 mg, 0.41 mmol) as a starting material and iodotrimethysilane (0.47 mL, 3.3 mmol). Compound 3g (50 mg, 0.14 mmol) was obtained as a colorless solid, in 34% yield, which was characterized as follows:

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-18810f33b5d44aa1875935c0edbfb3c8
Source dataset
uspto-grants-2013_08
Patent number
US08501709B2

Reaction notes

Loading…