Ethyl isothiocyanate → HCID 68313114, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of the compound obtained in example 1 section d (100 mg, 0.30 mmol) in CH2Cl2 (2 mL), ethyl isothiocyanate (0.042 ml, 0.48 mmol), EDC.HCl (171 mg, 0.89 mmol) and DIPEA (0.25 ml, 1.49 mmol) were added. The reaction mixture was heated in a CEM Explorer microwave oven at 80° C. and 150 W for 30 min. Then, it was evaporated to dryness. The crude product thus obtained was chromatographed over silica gel using MeOH/EtOAc mixtures of increasing polarity as eluent, to afford 42 mg of the desired compound (36% yield).

Provenance & Evidence