Sulfuryl chloride → HCID 57647079, compound

HRID 1887077Notes

Reaction equation

HRID 1887077 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][CH:6]=[CH:5]2.S(Cl)([Cl:15])(=O)=O>>[Cl:15][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[CH:8]=[N:7][CH:6]=1

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 218898476-Fluoroisoquinoline

Product 1

HCID 57647079HCID 57647079, compound

Procedure

A solution of 1.5 g 6-fluoro-isoquinoline (23) in 4.5 ml sulfuryl chloride was heated to 60° C. in a microwave reactor (CEM Discovery) for 8 h. After cooling to room temperature the mixture was poured on ice and extracted three times with CHCl3. After drying over Na2SO4 the solvent was distilled off and the crude product was purified by flash chromatography to yield 930 mg of compound 24.

Workup

  1. additionwas poured on ice
  2. extractionextracted three times with CHCl3
  3. dry with materialAfter drying over Na2SO4 the solvent
  4. distillationwas distilled off
  5. customthe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-c1158fc7cf5b436db6eb6477d475694f
Source dataset
uspto-grants-2013_08
Patent number
US08501736B2

Reaction notes

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