HCID 57646779, compound → HCID 57646872, compound

HRID 1887100Notes

Reaction equation

HRID 1887100 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:16]([F:26])=[C:17]3[C:22](=[CH:23][C:24]=2[F:25])[CH:21]=[N:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C>CO>[F:26][C:16]1[C:15]([O:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[C:24]([F:25])[CH:23]=[C:22]2[C:17]=1[CH:18]=[CH:19][N:20]=[CH:21]2

Participants

3

Reactant 1

HCID 57646779HCID 57646779, compound

Product 1

HCID 57646872HCID 57646872, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(5,7-Difluoro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (374) is deprotected in Methanol/2 N HCl by the general procedure described in AAV2 to yield the title compound as HCl-salt. Rt=0.43 min (Method #TOP). Detected mass: 265.1 (M+H+).

Sources & evidence

ORD record
ord-6ce9cfb8e42d4385ba9f634b08956616
Source dataset
uspto-grants-2013_08
Patent number
US08501736B2

Reaction notes

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