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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1887130Generated: October 31, 2026

2H-Pyran, 4-chlorotetrahydro- → 1-(Tetrahydropyran-4-yl)-4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazine

https://huagongshe.com/reaction/1887130

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2H-Pyran, 4-chlorotetrahydro-HCID 137202—
Reactant4-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazineHCID 67145002—
Product1-(Tetrahydropyran-4-yl)-4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazineHCID 15951385—

Reaction Steps

The title compound was prepared by a similar procedure to that described in Example 57, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 4-chloro-tetrahydropyran.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08501739B2
Source datasetuspto-grants-2013_08
ORD IDord-b55e5a0b55ab4ec385a2a8e3c16c9c2c
Source noteuspto-grants-2013_08