1,4'-Bipiperidine → 1'-[6-(Pyridin-4-yl)pyridazin-3-yl]-1,4'-bipiperidine

HRID 1887176Notes

Reaction equation

HRID 1887176 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[N:14]1([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[N:11]1[CH:12]=[CH:13][C:8]([C:5]2[N:4]=[N:3][C:2]([N:23]3[CH2:24][CH2:25][CH:20]([N:14]4[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]4)[CH2:21][CH2:22]3)=[CH:7][CH:6]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 786071,4'-BipiperidineHCID 130594283-Chloro-6-(pyridin-4-yl)pyridazine

Product 1

HCID 580066191'-[6-(Pyridin-4-yl)pyridazin-3-yl]-1,4'-bipiperidine

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-pyridin-4-yl-pyridazine and 4-piperidinopiperidine. 1H NMR (400 MHz, DMSO-d6) δ 8.67 (dd, 2H), 8.04 (m, 3H), 7.40 (d, 1H), 4.53 (d, 2H), 2.95 (t, 2H), 2.56 (m, 1H), 2.45 (m, 4H), 1.82 (d, 2H), 1.48 (m, 6H) 1.38 (m, 2H).

Sources & evidence

ORD record
ord-97c3d0533706450fb5c95f0bdd411ff4
Source dataset
uspto-grants-2013_08
Patent number
US08501739B2

Reaction notes

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