Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (2-Hydroxyphenyl)boronic acid | HCID 2773454 | — |
| Reactant | (2-Amino-6-iodoquinazolin-4-yl)isoindolin-2-ylmethanone | HCID 58457195 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59483453 | HCID 59483453 | — |
Reaction Steps
39.8 mg of 2-hydroxybenzeneboronic acid, 100 mg of potassium carbonate, 4.2 μl of water and 9.8 mg of [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) are added to a solution of 100 mg of 2-amino-6-iodo-4-(1,3-dihydroisoindol-2-ylcarbonyl)quinazoline in 3 ml of ethanol under argon. The mixture is heated at 80° C. for 12 h. The mixture is evaporated to dryness in vacuo, the residue is taken up in 1 ml of dimethyl sulfoxide and purified by chromatography (reversed phase HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08501754B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-b90ed0f2b264497298f13d5c1bc0623e |
|---|
| Source note | uspto-grants-2013_08 |
|---|
