4-Fluorobenzylamine → 2-Bromo-N-(3,4-difluorobenzyl)-4-methylthiazole-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Fluorobenzylamine	HCID 67326	—
Reactant	3,4-Difluorobenzylamine	HCID 123572	—
Reactant	2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid	HCID 2824058	—
Product	2-Bromo-N-(3,4-difluorobenzyl)-4-methylthiazole-5-carboxamide	HCID 66631177	50%

Reaction Steps

Following the procedure as described in Preparation 15, making variations only as requires to use (3,4-difluorophenyl)methanamine to replace (4-fluorophenyl)-methanamine to react with 2-bromo-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 50% yield: 1H NMR (300 MHz, CDCl3) δ 7.16-7.01 (m, 3H), 6.08-5.94 (m, 1H), 4.52 (d, J=5.9 Hz, 2H), 2.64 (s, 3H); MS (ES+) m/z 347.2 (M+1), 349.2 (M+3).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501746B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-699b9465bccd409a8d485b8fde066a84
Source note	uspto-grants-2013_08