Benzylamine → HCID 24985101, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-methoxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with benzylamine, the title compound was obtained as a colorless solid in 17% yield: mp 205-208° C. (hexane/ethyl acetate); 1H NMR (300 MHz, DMSO-d6) δ 8.78 (t, J=6.0 Hz, 1H), 8.59 (d, J=8.1 Hz, 1H), 7.35-7.17 (m, 5H), 6.33 (dd, J=8.1, 2.7 Hz, 1H), 6.11 (d, J=2.7 Hz, 1H), 4.38 (d, J=6.0 Hz, 2H), 3.81 (s, 3H), 2.54 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 168.6, 161.9, 161.6, 153.9, 150.3, 139.9, 132.0, 128.7, 127.2, 123.7, 104.2, 86.5, 56.8, 43.1, 17.5; MS (ES+) m/z 356.2 (M+1).

Provenance & Evidence