3-Pyridinemethanamine → HCID 178433081, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methyl-1H-imidazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with 3-(aminomethyl)pyridine, the title compound was obtained as a colorless solid in 63% yield: mp 203-204° C.; 1H NMR (300 MHz, DMSO-d6) δ 12.70 (br s, 1H), 8.58-8.51 (m, 2H), 8.43 (d, J=3.9 Hz, 1H), 8.01 (d, J=7.8 Hz, 1H), 7.70 (d, J=7.8 Hz, 1H), 7.50-7.29 (m, 6H), 6.23 (dd, J=7.8, 2.6 Hz, 1H), 6.07 (d, J=2.6 Hz, 1H), 5.16 (s, 2H), 4.40 (d, J=6.3 Hz, 2H), 2.47 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 167.2, 162.9, 162.0, 148.8, 147.8, 137.3, 135.9, 135.6, 135.4, 135.1, 130.8, 128.5, 128.2, 128.0, 127.4, 123.3, 101.6, 97.5, 70.0, 10.5; MS (ES+) m/z 416.3 (M+1).

Provenance & Evidence