Benzylamine → HCID 24985789, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-1,4-dimethyl-1H-imidazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with benzylamine, the title compound was obtained as a colorless solid in 62% yield: mp 232-233° C.; 1H NMR (300 MHz, CDCl3) δ 7.43-7.29 (m, 10H), 7.19 (d, J=7.7 Hz, 1H), 6.17 (t, J=5.6 Hz, 1H), 6.09 (dd, J=7.7, 2.5 Hz, 1H), 5.96 (d, J=2.5 Hz, 1H), 5.02 (s, 2H), 4.62 (d, J=5.6 Hz, 2H), 3.67 (s, 3H), 2.39 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 168.3, 163.3, 160.9, 141.5, 138.0, 137.8, 136.8, 134.7, 128.84, 128.8, 128.6, 127.7, 127.7, 127.6, 123.5, 102.8, 97.8, 70.6, 43.6, 32.7, 15.2; MS (ES+) m/z 429.3 (M+1).

Provenance & Evidence