Benzylamine → HCID 24985790, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with benzylamine, the title compound was obtained as a colorless solid in 76% yield: mp 190-191° C.; 1H NMR (300 MHz, CDCl3) δ 7.43-7.29 (m, 10H), 7.21 (d, J=7.7 Hz, 1H), 6.08 (dd, J=7.7, 2.5 Hz, 1H), 5.98 (d, J=2.5 Hz, 1H), 5.04 (s, 2H), 4.56 (d, J=6.1 Hz, 2H), 3.39 (s, 3H), 2.63 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 168.3, 163.4, 163.1, 138.6, 138.4, 137.1, 134.7, 133.5, 129.1, 128.8, 128.7, 128.5, 127.8, 127.7, 127.2, 102.7, 97.8, 70.6, 42.7, 30.6, 10.0; MS (ES+) m/z 429.3 (M+1).

Provenance & Evidence