3-Pyridinemethanamine → HCID 24984278, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-methoxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with pyridin-3-ylmethanamine, the title compound was obtained as a colorless solid in 58% yield: mp 200-202° C. (dichloromethane/methanol); 1H NMR (300 MHz, CDCl3) δ 8.64 (d, J=8.1 Hz, 1H), 8.60-8.59 (m, 1H), 8.52-8.51 (m, 1H), 7.51-7.68 (m, 1H), 7.29-7.24 (m, 1H), 6.30 (t, J=5.8 Hz, 1H), 6.17 (dd, J=8.1, 2.6 Hz, 1H), 5.96 (d, J=2.6 Hz, 1H), 4.61 (d, J=5.8 Hz, 2H), 3.82 (s, 3H), 2.67 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 168.4, 162.4, 162.1, 153.6, 152.6, 149.2, 149.0, 135.7, 133.7, 131.4, 123.6, 121.8, 103.9, 96.2, 56.0, 41.4, 17.3; MS (ES+) m/z 357.2 (M+1).

Provenance & Evidence