3-Fluorobenzylamine → HCID 54742333, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with (3-fluorophenyl)methanamine, the title compound was obtained as a colorless solid in 44% yield: mp 250-252° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 11.50 (br s, 1H), 8.78 (t, J=6.0 Hz, 1H), 8.59 (d, J=8.0 Hz, 1H), 7.39-7.30 (m, 1H), 7.13-7.00 (m, 3H), 6.26 (dd, J=8.0, 2.5 Hz, 1H), 5.82 (d, J=2.5 Hz, 1H), 4.39 (d, J=5.9 Hz, 2H), 2.53 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 167.9, 164.2, 162.1, 161.6, 154.2, 142.9, 142.8, 132.6, 130.7, 123.7, 123.4, 114.5, 114.1, 104.4, 98.0, 42.6, 17.5; MS (ES+) m/z: 360.2 (M+1).

Provenance & Evidence