反应详情

Following the procedure as described in Example 1, making variations only as required to use 2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with 2-cyclopropylethanamine, the title compound was obtained as a colorless solid in 64% yield: mp 234-236° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 11.47 (s, 1H), 8.58 (d, J=8.0 Hz, 1H), 8.16 (t, J=5.6 Hz, 1H), 6.25 (dd, J=8.0, 2.6 Hz, 1H), 5.81 (d, J=2.5 Hz, 1H), 3.26-3.20 (m, 2H), 2.50 (s, 3H), 1.40-1.34 (m, 2H), 0.76-0.59 (m, 1H), 0.39-0.33 (m, 2H), 0.03-0.01 (m, 2H); 13C NMR (75 MHz, DMSO-d6) δ 167.8, 161.8, 161.6, 153.9, 149.4, 132.6, 124.2, 104.3, 98.0, 39.9, 34.4, 17.4, 9.0, 4.6; MS (ES+) m/z 320.2 (M+1).