p-Fluorophenethylamine → N-(4-Fluorophenethyl)-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

関与物質

反応手順

Following the procedure as described in Example 1, making variations only as required to use 2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with 2-(4-fluorophenyl)ethanamine, the title compound was obtained as a colorless solid in 69% yield: mp 225-227° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 11.47 (s, 1H), 8.57 (d, J=8.0 Hz, 1H), 8.23 (t, J=5.5 Hz, 1H), 7.25-7.18 (m, 2H), 7.12-7.04 (m, 2H), 6.25 (dd, J=8.0, 2.6 Hz, 1H), 5.81 (d, J=2.5 Hz, 1H), 3.42-3.35 (m, 2H), 2.78 (t, J=7.2 Hz, 2H), 2.50 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 167.8, 161.9, 161.6, 159.6, 154.1, 149.6, 136.0, 132.6, 130.9, 124.0, 115.5, 104.3, 98.0, 41.2, 34.5, 17.3; MS (ES+) m/z 374.2 (M+1).

情報源と証拠