Oxazol-2-ylmethanamine → 2-(4-Hydroxy-2-oxopyridin-1(2H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with oxazol-2-ylmethanamine, the title compound was obtained as a colorless solid in 25% yield: 1H NMR (300 MHz, DMSO-d6) δ 11.51 (s, 1H), 8.84 (t, J=5.7 Hz, 1H), 8.59 (d, J=8.0 Hz, 1H), 8.02 (s, 1H), 7.12 (s, 1H), 6.26 (dd, J=8.0, 2.5 Hz, 1H), 5.82 (d, J=2.5 Hz, 1H), 4.48 (d, J=5.7 Hz, 2H), 2.53 (s, 3H); MS (ES+) m/z 333.2 (M+1).

Provenance & Evidence