3-Pyridinemethanamine → HCID 57744468, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use 5-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-3-methylthiophene-2-carboxylic acid in place of 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylic acid to react with 3-(aminomethyl)pyridine, the title compound was obtained as a colorless solid in 39% yield: mp 165-167° C.; 1H NMR (300 MHz, CDCl3) δ 8.61 (d, J=1.5 Hz, 1H), 8.54 (dd, J=4.7, 1.5 Hz, 1H), 7.71 (dt, J=7.8, 1.5 Hz, 1H), 7.57 (d, J=7.8 Hz, 1H), 7.43-7.27 (m, 6H), 6.85 (s, 1H), 6.30 (t, J=5.8 Hz, 1H), 6.15 (dd, J=7.8, 2.7 Hz, 1H), 6.06 (d, J=2.7 Hz, 1H), 5.04 (s, 2H), 4.61 (d, J=5.8 Hz, 2H), 2.54 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 166.2, 162.6, 160.9, 138.8, 137.5, 135.4, 135.0, 128.5, 128.2, 128.0, 126.9, 120.5, 102.6, 97.3, 70.0, 15.5; MS (ES+) m/z 432.2 (M+1).

Provenance & Evidence