2-Pyridone → HCID 24985271, compound

Participants

Reaction Steps

Following the procedure as described in Example 3, making variations only as required to use pyridin-2(1H)-one in place of 4-aminopyridin-2(1H)-one to react with N-benzyl-2-bromo-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 48% yield: mp 180-182° C. (hexane/ethyl acetate); 1H NMR (300 MHz, CDCl3) δ 8.83 (t, J=5.9 Hz, 1H), 8.71 (dd, J=7.3, 1.7 Hz, 1H), 7.65-7.59 (m, 1H), 7.37-7.18 (m, 5H), 6.74 (d, J=9.3 Hz, 1H), 6.60-6.55 (m, 1H), 4.39 (d, J=5.9 Hz, 2H), 2.56 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 167.9, 162.0, 161.6, 154.1, 150.2, 139.9, 132.6, 128.7, 127.7, 127.2, 123.6, 104.4, 98.0, 43.1, 17.5; (ES+) m/z 326.1 (M+1).

Provenance & Evidence