4-Benzyloxy-2(1H)-pyridone → HCID 24983972, compound

Participants

Reaction Steps

Following the procedure as described in Example 3, making variations only as required to use 4-(benzyloxy)pyridin-2(1H)-one in place of 4-aminopyridin-2(1H)-one to react with 2-bromo-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide in place of N-benzyl-2-bromo-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 47% yield: mp 208-209° C.; 1H-NMR (300 MHz, DMSO-d6) δ 8.86 (br s, 1H), 8.68-8.60 (m, 1H), 7.81-7.72 (m, 1H), 7.51-7.33 (m, 7H), 6.35-6.48 (m, 1H), 6.27 (s, 1H), 5.19 (s, 2H), 4.47 (s, 2H), 2.58 (s, 3H); 13C NMR (75 MHz, DMSO-d6) δ 167.0, 161.5, 161.1, 153.5, 150.1, 135.2, 131.6, 128.5, 128.3, 128.0, 122.9, 103.9, 97.0, 70.3, 17.0; MS (ES+) m/z: 433.3 (M+1).

Provenance & Evidence