Furan, 2-(bromomethyl)tetrahydro- → HCID 57744449, compound

Participants

Reaction Steps

Following the procedure as described in Example 9, making variation only as required to use 2-(bromomethyl)tetrahydrofuran in place of 2-cyclopropylethyl 4-methylbenzenesulfonate to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 42% yield: mp 181-183° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.66-8.62 (m, 1H), 7.38-7.26 (m, 5H), 6.22-6.18 (m, 1H), 6.14-6.12 (m, 1H), 5.95-5.94 (m, 1H), 4.58-4.54 (m, 2H), 4.33-4.20 (m, 1H), 3.99-3.78 (m, 4H), 2.67 (s, 3H), 2.13-1.90 (m, 3H), 1.77-1.66 (m, 1H); MS (ES+) m/z 426.3 (M+1), 448.3 (M+23).

Provenance & Evidence