4-Benzyloxy-2(1H)-pyridone → HCID 24985949, compound

Participants

Reaction Steps

Following the procedure as described in Example 12, making variations only as required to use 4-(benzyloxy)pyridin-2(1H)-one in place of 4-phenylpyridin-2-ol to react with ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate in place of ethyl 2-bromo-4-methylthiazole-5-carboxylate at 125° C. for 64 hours, the title compound was obtained as a colorless solid in 24% yield: 1H NMR (300 MHz, CDCl3) δ 7.44-7.36 (m, 5H), 7.22 (d, J=7.7 Hz, 1H), 6.09 (dd, J=7.7, 2.5 Hz, 1H) 5.98 (d, J=2.5 Hz, 1H), 5.04 (s, 2H), 4.35 (q, J=7.1 Hz, 2H), 3.69 (s, 3H), 2.49 (s, 3H), 1.38 (t, J=7.1 Hz, 3H); MS (ES+) m/z 368.2 (M+1).

Provenance & Evidence