Acetic Acid → HCID 24985951, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylate (0.25 g, 0.74 mmol) in a mixture of tetrahydrofuran (4 mL) and water (4 mL) was added lithium hydroxide (0.14 g, 3.68 mmol). The reaction mixture was heated at 50° C. for 4 hours, then cooled to ambient temperature and acidified to pH 6 with acetic acid. The solid obtained was collected by filtration, washed with water and dried in air. The title compound was obtained as a yellowish solid (0.20 g, 87%): MS (ES+) m/z 313.5 (M+1).

Provenance & Evidence